Faculty Advisor

Pins, George D

Abstract

Heart disease is the leading cause of death worldwide. Myocardial infarction (MI) is a primary symptom of heart disease and leads to heart failure. Current treatments for MI include pharmaceuticals and implanted assistive devices, but they do not restore full function to the damaged tissue. Fibrin cardiac patches have shown promise as a regenerative solution, but lack similarity to native tissue. The goal of this project was to develop a low-cost device to stimulate engineered fibrin cardiac patches to improve their functional properties. Cardiac patches seeded with C2C12 cells were used for proof-of-concept and analyzed for myoblast proliferation and alignment. Initial findings indicated that our device is capable of imparting consistent uniaxial strains onto live cardiac patches.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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