Rolle, Marsha Whitney
Whittington, Catherine Faye
Intimal hyperplasia (IH) is a prevalent disease characterized by lesion formation on blood vessels through cell growth at the site of an injury. A tissue engineered blood vessel model of IH could facilitate drug development. The team designed microspheres that can release growth factor to stimulate lesion formation by localized proliferation in a vessel model. Based on design objectives and constraints, the team tested and evaluated four microsphere materials for biocompatibility, size distribution, protein encapsulation, protein release, and retention of protein activity. After testing, it was determined that silk microspheres showed the greatest promise for use in the IH model and the team suggests assessing its functionality once incorporated into the vessel model.
Worcester Polytechnic Institute
Major Qualifying Project
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