Student Work

Protein Releasing Microspheres for an In Vitro Intimal Hyperplasia Model

Public

Downloadable Content

open in viewer

Intimal hyperplasia (IH) is a prevalent disease characterized by lesion formation on blood vessels through cell growth at the site of an injury. A tissue engineered blood vessel model of IH could facilitate drug development. The team designed microspheres that can release growth factor to stimulate lesion formation by localized proliferation in a vessel model. Based on design objectives and constraints, the team tested and evaluated four microsphere materials for biocompatibility, size distribution, protein encapsulation, protein release, and retention of protein activity.\nAfter testing, it was determined that silk microspheres showed the greatest promise for use in the IH model and the team suggests assessing its functionality once incorporated into the vessel model.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042519-122450
Advisor
Year
  • 2019
Date created
  • 2019-04-25
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/8k71nk61t