Faculty Advisor

Srinivasan, Jagan

Abstract

One of the most prominent addictions of the modern age is to opioids. While opioids originated as a pain relief treatment, their use has increased in the United States steadily since 1990. To study the impact of opioids on a compact neurological system, the model roundworm Caenorhabditis elegans was used. Beta-Endorphin, an endogenous human opioid, was administered to C. elegans and observed for changes in locomotive behavior. Our results revealed a reduction of speed of the worms treated with beta-Endorphin versus a water control. These findings suggest that beta- Endorphin has an effect on C. elegans and can be useful model in studying addiction in these systems

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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