A new technique, surface inhibited nucleation, to control the selective growth of pharmaceutical polymorphs is reported. This technique uses perfluoroalkyl silane monolayers as nonstick surfaces for the exclusive growth of stable polymorph of indomethacin. This selectivity can be reversed by using a drug for which the crystal faces are bounded by fluorous surfaces, as is the case of flufenamic acid. This technique can significantly increase the probability of finding stable polymorphs at the early stages of pharmaceutical development.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Ferris, Lori A.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042607-145921

Advisor

• Thalladi, Venkat R.

Year

• 2007

Date created

• 2007-04-26

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright