Thalladi, Venkat R.
A new technique, surface inhibited nucleation, to control the selective growth of pharmaceutical polymorphs is reported. This technique uses perfluoroalkyl silane monolayers as nonstick surfaces for the exclusive growth of stable polymorph of indomethacin. This selectivity can be reversed by using a drug for which the crystal faces are bounded by fluorous surfaces, as is the case of flufenamic acid. This technique can significantly increase the probability of finding stable polymorphs at the early stages of pharmaceutical development.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry