Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Promensil is a plant-based postmenopausal medication containing phytoestrogens that mimic the structure of estrogen. Cell line treatments with Promensil were performed to study if it had any influence on the cell cycle regarding specific cell cycle proteins. Furthermore, T47D cells were administered MPP, an estrogen receptor-α specific antagonist, to verify if the Promensil antiproliferative mechanism is estrogen receptor-α mediated. Due to a variety of issues, it was not possible to make any conclusions about the effects of Promensil on the cell cycle. Promensil effects were still seen in cells treated with MPP, therefore it was determined that the antiproliferative effector pathway of Promensil is not estrogen receptor-α mediated, thus refuting the hypothesis.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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