Faculty Advisor

Manning, Amity L.

Abstract

Recent advances in whole transcriptome sequencing have revealed that the majority of the genome is transcribed but only 1% of transcripts are coded for protein biosynthesis. This remaining ‘junk DNA’ includes non-coding RNA species (ncRNA), which have been implicated in modulating tumorigenesis as well as tumor suppression if they are misexpressed. Recent experiments indicate that loss of the Retinoblastoma tumor suppressor protein (pRB), a transcriptional co-regulator, alters the expression of both coding and non-coding transcripts. This project seeks to understand if misexpression of these ncRNAs plays a role in the pleiotropic effects of pRB loss in cancer.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Share

COinS