Canton-Potsdam Hospital (PW)
Stress Granules (SGs) are cytoplasmic bodies where mRNAs are stored during cellular stress to inhibit their translation. FMRP localizes to SGs and regulates mRNA translation; we hypothesized that SGs may differ in FXS and unaffected cells. Our results suggest altered stress responses may contribute to the pathophysiology of FXS. Additionally, literature shows that patients with intellectual and developmental disabilities (IDD) experience an increased rate of ED admissions. I hypothesized that IDD individuals would have different trends in their diagnoses due to the differing stress response. I studied a group of IDD individuals' ED visits compared to national averages and the infection and injury rates were found to be elevated.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.
Humanities and Arts
Biology and Biotechnology