Faculty Advisor

Faber, Brenton

Faculty Advisor

Farny, Natalie

Abstract

Stress Granules (SGs) are cytoplasmic bodies where mRNAs are stored during cellular stress to inhibit their translation. FMRP localizes to SGs and regulates mRNA translation; we hypothesized that SGs may differ in FXS and unaffected cells. Our results suggest altered stress responses may contribute to the pathophysiology of FXS. Additionally, literature shows that patients with intellectual and developmental disabilities (IDD) experience an increased rate of ED admissions. I hypothesized that IDD individuals would have different trends in their diagnoses due to the differing stress response. I studied a group of IDD individuals' ED visits compared to national averages and the infection and injury rates were found to be elevated.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Interdisciplinary

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Humanities and Arts

Advisor Department

Biology and Biotechnology

Share

COinS