Faculty Advisor

Duffy, Joseph B.

Abstract

ErbB1-4 are members of the human epidermal growth factor receptor (EGFR) family of tyrosine kinases. ErbB2 has been implicated in many different types of cancer,most notably breast cancer. Structural studies reveal that ErbB2 and the Drosophila EGFR (DER) share significant similarity. DER is known to be inhibited by Kekkon 1, a transmembrane leucine-rich repeat immunoglobulin, or LIG protein. To investigate the mechanism of binding to DER and determine if Kek1 could bind ErbB2, an enzyme-linked extracellular interaction screen (ELEXIS) was utilized.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2016

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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