Faculty Advisor

Farny, Natalie

Abstract

The protein FMRP is missing in Fragile X Syndrome (FXS) patients. Stress Granules (SGs) are cytoplasmic bodies where mRNAs are stored during cellular stress to inhibit their translation. FMRP localizes to SGs and regulates mRNA translation; therefore we hypothesized that SGs may differ in FXS and unaffected cells. We used fluorescence microscopy to quantify SG formation in wild type and FXS mouse embryonic fibroblasts and human B lymphocytes. Our results suggest altered stress responses may contribute to the pathophysiology of FXS.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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