Lung Levels of Neutrophil-Related Chemokines S100A8 and CXCL5 Do Not Correlate With Mycobacterium tuberculosis Levels in 8 Mouse Strains
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open in viewerThe purpose of this project was to determine whether neutrophil-related proteins, S100A8 and CXCL5 correlate with the levels of Mycobacterium tuberculosis in mouse models, and explore whether these proteins could be used as indicators of disease progression. Their concentrations in the lungs were calculated using sandwich ELISAs, and bacterial lung burdens were calculated from Colony Forming Units (CFUs) on agar plates. Final analyses showed no correlation between neutrophil chemokines and M. tuberculosis burden, and that mice had no weight loss throughout the experimental timeframe. Therefore, when there is a weight gain, lung concentrations of S100A8 and CXCL5 cannot be used as indicators of disease progression in TB.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042219-151248
- Advisor
- Year
- 2019
- Sponsor
- Date created
- 2019-04-22
- Resource type
- Major
- Rights statement
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