Faculty Advisor

Billiar, Kristen

Abstract

To study mechanobiology, cells are deformed uniaxially or biaxially and cell behavior is observed. The devices that currently exist on the market for stretching cells come at a high cost, cannot be custom programmed, and typically lack both uniaxial and biaxial functionality. The primary goal of our project was to develop a precise cell stretching device for biaxial strain application at different magnitudes, rates, and patterns to observe cellular effects. To develop a custom device with stretching functionality, our team designed and tested multiple motor-based cell stretching devices. The final design consists of a low profile, four linear actuator stretching system which successfully stretches cells at a range of strains, frequencies, and strain patterns over a 24-hour period.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2019

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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