To study mechanobiology, cells are deformed uniaxially or biaxially and cell behavior is observed. The devices that currently exist on the market for stretching cells come at a high cost, cannot be custom programmed, and typically lack both uniaxial and biaxial functionality. The primary goal of our project was to develop a precise cell stretching device for biaxial strain application at different magnitudes, rates, and patterns to observe cellular effects. To develop a custom device with stretching functionality, our team designed and tested multiple motor-based cell stretching devices. The final design consists of a low profile, four linear actuator stretching system which successfully stretches cells at a range of strains, frequencies, and strain patterns over a 24-hour period.
Worcester Polytechnic Institute
Major Qualifying Project
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