Faculty Advisor

Adams, David S.

Center

UMMC / University of Massachusetts Medical Center

Abstract

Every year millions of people contract HIV or die from HIV-AIDS related illnesses. Since current drugs generally target viral enzymes, selective drug pressure coupled with the high mutation rate and infidelity of HIV-1 reverse transcriptase lead to drug resistance. It is thus crucial to develop new, tighter-binding inhibitors with more flexible structures that can better inhibit mutant proteases. Two novel inhibitor cores were designed and synthesized, all while attempting to stay within the confines of the substrate-envelope. Many new drugs were tested, which bound to various drug-resistant mutants in the pM range.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Share

COinS