Rolle, Marsha Whitney
Acne is the eighth most prevalent disease worldwide. Current treatments include over-the- counter and prescription options, both of which are inadequate due to adverse effects such as redness and inflammation of the skin, and antibiotic resistance on the rise, respectively. Antimicrobial peptides (AMPs) have been investigated as a promising alternative, but have suffered due to their high cost, cytotoxic risk and challenge of delivering a large protein through the skin barrier. This project aimed to develop a topical antimicrobial peptide delivery vehicle to deliver modified AMP fCBD-LL37 to the sebaceous glands in the skin for the safe and effective treatment of acne vulgaris.
Worcester Polytechnic Institute
Major Qualifying Project
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