Faculty Advisor

Page, Raymond L.

Abstract

Muscle myopathies cause high fatality rates and lack effective clinical drug treatments. Currently, there are no in vitro skeletal muscle tissue models that precisely mimic native human muscle morphology and function due to a lack of maturation. Animal models also fail to provide clinically-relevant data due to a lack of genetic homology to humans. Therefore, drug efficacy cannot be accurately tested pre-clinically before human clinical trials. To improve in vitro skeletal muscle tissue maturation, a device was designed to mechanically stimulate skeletal muscle tissue. The device effectively provided a morphological difference in C2C12 myoblast as well as primary human myoblast derived tissue constructs, with less necrosis and greater myofiber alignment compared to the static constructs.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biomedical Engineering

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