Page, Raymond L.
Muscle myopathies cause high fatality rates and lack effective clinical drug treatments. Currently, there are no in vitro skeletal muscle tissue models that precisely mimic native human muscle morphology and function due to a lack of maturation. Animal models also fail to provide clinically-relevant data due to a lack of genetic homology to humans. Therefore, drug efficacy cannot be accurately tested pre-clinically before human clinical trials. To improve in vitro skeletal muscle tissue maturation, a device was designed to mechanically stimulate skeletal muscle tissue. The device effectively provided a morphological difference in C2C12 myoblast as well as primary human myoblast derived tissue constructs, with less necrosis and greater myofiber alignment compared to the static constructs.
Worcester Polytechnic Institute
Major Qualifying Project
Access to this report is limited to members of the WPI community. Please contact a project advisor or their department to request access
Restricted-WPI community only
Your accessibility may vary due to other restrictions.