Faculty Advisor

Brodeur, Drew R

Faculty Advisor

Kmiotek, Stephen J.

Abstract

The student worked with Pfizer Inc. to study the feasibility of an immobilized enzyme in the preparation of an intermediate to Glasdegib, a Phase I clinical SMO inhibitor that has shown promise in the inhibition of tumor growth for human colorectal and pancreatic cancers. The project resulted in an optimization of one immobilized resin based on the activity of the enzyme, enzyme stability in organic solvents, and reuse of the biocatalyst as well as a preliminary scale-up study utilizing AspenPlus.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Interdisciplinary

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

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