Brodeur, Drew R
Kmiotek, Stephen J.
The student worked with Pfizer Inc. to study the feasibility of an immobilized enzyme in the preparation of an intermediate to Glasdegib, a Phase I clinical SMO inhibitor that has shown promise in the inhibition of tumor growth for human colorectal and pancreatic cancers. The project resulted in an optimization of one immobilized resin based on the activity of the enzyme, enzyme stability in organic solvents, and reuse of the biocatalyst as well as a preliminary scale-up study utilizing AspenPlus.
Worcester Polytechnic Institute
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