Faculty Advisor

Clark, William M.

Abstract

Experiments were designed to confirm the reliability of an Aspen Plus model simulating an active pharmaceutical ingredient recovery process for Sunovion Pharmaceuticals. The process includes a reaction between a triflate salt compound and potassium hydroxide, followed by a liquid-liquid extraction with methyl tert-butyl ether. The experiments looked to verify the previous work, study the effects of pH above pKa on the reaction, and study the effects of temperature on the extraction. Other solvents were examined for feasibility in the process.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Chemical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemical Engineering

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