Faculty Advisor

Korkin, Dmitry

Faculty Advisor

Manning, Amity L.

Abstract

There are many methods to analyze cell nuclei, but few can detect the presence of DNA damage, without labeling proteins. We have developed a process to detect and classify cell nuclei in the presence of DNA damage. This method uses the morphology of DNA-associated histone proteins, without proteins that specifically label or localize to sites of DNA damage.. We discuss how and why we address this problem, followed by the specifics of the program pipeline, then our results and how it compares to other methods, and concluding about future additions.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-06

Major

Interdisciplinary

Major

Computer Science

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Computer Science

Advisor Department

Biology and Biotechnology

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