Olsen, Carissa Lynn
Obesity is an increasing health problem across the United States, and green coffee bean extract (GCBE) may be a useful supplement to promote weight loss in humans; however, this supplement is anecdotal. GCBE has shown decreased fat accumulation in model organisms, and further studies in these systems help to elucidate the mechanism behind how green coffee bean extract is decreasing fat storage. Here, GCBE was supplemented in studies through high and low fat strains of C. elegans to observe pathways to determine whether this supplement is a viable option for tackling obesity. Through those pathways, the relationship between fat in the membrane and total fat content of the model organism will be more defined and ultimately aid in determining if GCBE is a safe and effective weight loss aid.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry