Faculty Advisor

Heilman, Destin

Abstract

Directed evolution is a powerful tool used to create improved proteins. Despite its promise, the growing complexity of directed evolution systems limits their transferability. This paper details a Bacterial Non-Continuous Evolution model (BaNCE) that aims to conserve the power of directed evolution while simplifying the process to make it accessible to a wider group of researchers. In addition to its design, experiments were performed to investigate the potential of this system and outline future steps for its development.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-12

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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