Dittami, James P.
MacDonald, John C.
A photocyclic cycloaddition reaction via an ylide intermediate has opened the way for the synthesis and testing of numerous biologically active scaffolds. Research has demonstrated that the incorporation of electron-rich systems, most significantly naphthyl systems, increases the efficiency of the photocyclic reaction. In this project, new possibilities for electron-rich naphthyl analogs have been explored, incorporating heteroatoms into the bicyclic aromatic system. These new structures have been selected on the criteria of Lipinski’s rules and feasibility of synthesis. A precursor to one of these structures was synthesized. Additionally, syntheses of other scaffold components were carried out.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry