Faculty Advisor

Dittami, James P.

Faculty Advisor

MacDonald, John C.

Abstract

A photocyclic cycloaddition reaction via an ylide intermediate has opened the way for the synthesis and testing of numerous biologically active scaffolds. Research has demonstrated that the incorporation of electron-rich systems, most significantly naphthyl systems, increases the efficiency of the photocyclic reaction. In this project, new possibilities for electron-rich naphthyl analogs have been explored, incorporating heteroatoms into the bicyclic aromatic system. These new structures have been selected on the criteria of Lipinski’s rules and feasibility of synthesis. A precursor to one of these structures was synthesized. Additionally, syntheses of other scaffold components were carried out.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2013

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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