Gaudette, Glenn R.
Fibrin microthreads are a biological material being used for targeted cell delivery, but exhibit variance in their mechanical properties. A mechanical microthread bundling device was designed to produce consistent and reproducible bundles. The mechanical properties, cell seedability, and twist consistency of prototype bundles were compared to hand-made samples. Hand-made samples were calculated to have a YS, UTS, and E of 0.390 ± 0.190, 1.066 ± 0.678, and 0.405 ± 0.168 MPa, respectively. Prototype produced bundles had a YS, UTS, and E of 0.196 ± 0.050, 0.537 ± 0.181, and 0.269 ± 0.158 MPa respectively. Prototype bundles were found to have an average of 1.65 ± 0.5 twists per cm. Average values and standard deviations for bundle mechanics were found to be lower for prototype bundles.
Worcester Polytechnic Institute
Major Qualifying Project