Faculty Advisor

Gaudette, Glenn R.

Abstract

Fibrin microthreads are a biological material being used for targeted cell delivery, but exhibit variance in their mechanical properties. A mechanical microthread bundling device was designed to produce consistent and reproducible bundles. The mechanical properties, cell seedability, and twist consistency of prototype bundles were compared to hand-made samples. Hand-made samples were calculated to have a YS, UTS, and E of 0.390 ± 0.190, 1.066 ± 0.678, and 0.405 ± 0.168 MPa, respectively. Prototype produced bundles had a YS, UTS, and E of 0.196 ± 0.050, 0.537 ± 0.181, and 0.269 ± 0.158 MPa respectively. Prototype bundles were found to have an average of 1.65 ± 0.5 twists per cm. Average values and standard deviations for bundle mechanics were found to be lower for prototype bundles.

Publisher

Worcester Polytechnic Institute

Date Accepted

July 2013

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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