Faculty Advisor

Manning, Amity L.

Faculty Advisor

Heilman, Destin

Abstract

The retinoblastoma protein is a tumor suppressant that is inactivated in almost all forms of cancer. One of the main functions of pRB is to prevent excessive cell growth prior to proliferation by inhibiting cell cycle progression. Over 300 proteins have been identified as interactors with pRB but the relevance of most of these interactions remains unclear. Since mitotic defects are observed when pRB is depleted, we hypothesize that pRB makes crucial and functionally relevant interactions with proteins that have important roles during mitosis. One candidate protein, Aurora B kinase, has an important role in mitotic chromosome segregation and has previously been suggested to interact with pRB in asynchronous cells. My analysis indicates that pRB and Aurora B likely interact in mitotic cells.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-14

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemistry and Biochemistry

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