Faculty Advisor

Srinivasan, Jagan

Faculty Advisor

Olsen, Carissa Lynn

Abstract

Environmental cues result in epigenetic alteration, or reprogramming, and play a role in transgenerational inheritance. C. elegans sense external cues through chemosensation and communicates to conspecifics through ascarosides. osas#9, has been shown to trigger avoidance response alterations across multiple generations. In this paper I show that pre-exposure to osas#9 triggers neurologic responses activating the serotonergic and glutamatergic pathways in adult C. elegans. In addition, pre-exposure causes H3K4 demethylation, down regulating transcription activation and avoidance behaviors. Studying how the nervous system senses the environment and the downstream genetic machinery that triggers epigenetic reprogramming is an essential part in understanding what builds us outside of genetics.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-14

Major

Biology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemistry and Biochemistry

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