Faculty Advisor

Coburn, Jeannine M

Faculty Advisor

Roberts, Susan Celia

Abstract

Taxus plant suspension cultures can be used to produce paclitaxel, an anticancer compound. Currently PTX is administered systemically, which can have severe side effects. To minimize these effects, this project investigates the use of a plant cell culture (PCC) delivery system for paclitaxel through exploring retention of paclitaxel and other specialized metabolites through PCC processing, optimization of drug delivery through various polymers, predicted release in an in vitro breast cancer model, and consideration of the pharmacokinetics of the optimized system.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-16

Major

Chemical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Advisor Department

Chemical Engineering

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