Faculty Advisor

Arguello, Jose' M.

Faculty Advisor

Rao, Reeta Prusty

Abstract

Candida albicans, an opportunistic pathogenic fungus, lives commensally in the human gut. Caenorhabditis elegans, an ideal host organism for microbiome studies, pre-exposed to the beneficial bacteria Bacillus subtilis are able to resist wildtype C. albicans infections and live longer than naive worms. We have identified C. albicans mutants that showed significant difference in lifespans of C. elegans with and without pre-exposure to B. subtilis. This approach will identify genes and pathways that modulate microbial interactions to alter host outcomes.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-16

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

Share

COinS