Faculty Advisor

Billiar, Kristen

Abstract

Tissue engineered heart valves are a promising solution to current problems with heart valve replacements. However, TEHVs contract when implanted. This project aims to design a device to mechanically stretch heart valve microtissues to test how conditioning can affect this contraction. This design adapted the current method used in the Billiar lab to form heart valve microtissues suspended between a fixed PDMS post and mobile stainless steel needle. A linear actuator moves the needles to stretch the tissues in increments. Stretch can be monitored optically and forces can be calculated to understand the effect of conditioning. The final design was proven conceptually but further tests with tissue samples should be completed.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-16

Major

Biomedical Engineering

Major

Mechanical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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