Faculty Advisor

Heilman, Destin

Abstract

The Circoviridae family of viruses have several members that encode proteins observed to induce apoptosis in human cells with specificity towards cancer cells. One unique example, PCV1-VP3, has significant morphological and functional differences, possessing an additional tail domain and localizing in the cytoplasm rather than the nucleus of transformed cells. To gain insight into possible mechanisms of action, compartmentalization of PCV1-VP3 was investigated using differential detergent fractionation and fluorescent microscopy.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-16

Major

Biology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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