Sabuncu, Ahmet Can
Page, Raymond L.
Most of the processes in the biomanufacturing industry utilize suspension bioreactor for the production of biologics, whereas there has been a slower development in large scale manufacturing involving adherent cell cultures. This project aims to design a novel bioreactor system which supports adherent cell culture, while improving upon cellular adherence and volumetric efficiency. The final design incorporated a packed bed of microcarriers within a continuous pumping system, thereby promoting bead-to-bead migration and the recycling of unattached cells. The system was tested for proper continuous fluid flow, and the microcarriers were optimized to maximize surface area and cellular attachment potential.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.