Faculty Advisor

Sabuncu, Ahmet Can

Faculty Advisor

Page, Raymond L.

Abstract

Most of the processes in the biomanufacturing industry utilize suspension bioreactor for the production of biologics, whereas there has been a slower development in large scale manufacturing involving adherent cell cultures. This project aims to design a novel bioreactor system which supports adherent cell culture, while improving upon cellular adherence and volumetric efficiency. The final design incorporated a packed bed of microcarriers within a continuous pumping system, thereby promoting bead-to-bead migration and the recycling of unattached cells. The system was tested for proper continuous fluid flow, and the microcarriers were optimized to maximize surface area and cellular attachment potential.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-18

Major

Biomedical Engineering

Major

Interdisciplinary

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Mechanical Engineering

Advisor Department

Biomedical Engineering

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