Faculty Advisor

Farny, Natalie

Faculty Advisor

Munson, Mary

Abstract

The exocyst complex plays roles in membrane trafficking and fusion during exocytosis. Current Cryo-EM models do not provide clear structural information on the complex or its CorEx bundles. CorEx bundles are involved in connecting the two exocyst modules, though the mechanism is poorly understood. We attempted to obtain a crystallized structure of a CorEx bundle by two methods: building the complex using a polycistronic plasmid system and digesting the complex by limited proteolysis.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-18

Major

Biology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology

Advisor Department

Chemistry and Biochemistry

Available for download on Thursday, May 18, 2023

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