Faculty Advisor

Manning, Amity L.

Abstract

The goal of this project is to determine whether cells with depleted pRB have a different level of motility than cells with sufficient pRB. This was tested using assays that specifically looked at the effects on individual cells and the ability of cells to move en masse. Cell density is known to impact cell motility. To mitigate this as a potential variable, data was controlled so that cells with or without pRB from populations of similar density were compared. Differential behavior at high and low densities was also compared. My data indicates that pRB- deficiency does not alter cell motility at the population level but instead increases the motility of a subpopulation of individual cells.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-18

Major

Biology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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