Manning, Amity L.
The goal of this project is to determine whether cells with depleted pRB have a different level of motility than cells with sufficient pRB. This was tested using assays that specifically looked at the effects on individual cells and the ability of cells to move en masse. Cell density is known to impact cell motility. To mitigate this as a potential variable, data was controlled so that cells with or without pRB from populations of similar density were compared. Differential behavior at high and low densities was also compared. My data indicates that pRB- deficiency does not alter cell motility at the population level but instead increases the motility of a subpopulation of individual cells.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology