Faculty Advisor

Whittington, Catherine Faye

Abstract

Fibrosis is pathological wound healing where sustained epithelial cell damage causes an overgrowth of connective tissue. This process leads to excessive tissue remodeling and scarring that can lead to total organ failure in the worst cases. Approximately 360,000 fibrosis-related cases arise in the U.S. alone, and about 54,000 of those cases occur in pancreatic cancer. Current in vitro models of fibrosis often lack the spatial heterogeneity observed in the tissue microstructure (e.g., fibril density, fibril alignment) that influences certain cell behaviors. The team was tasked with creating a 3D in vitro extracellular matrix with heterogeneous fibril density, alignment, and interstitial spacing that could be used for a pancreatic tumor model.

Publisher

Worcester Polytechnic Institute

Date Accepted

2020-05-18

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biomedical Engineering

Available for download on Tuesday, May 18, 2021

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