Faculty Advisor

Rolle, Marsha W.

Abstract

A potential application for tissue engineering is the development of functional, three-dimensional vascular constructs to aid in drug discovery. The goal of the project was to create a device that measures the contractile force of vascular ring constructs in response to chemical stimulation to model blood vessel function in vitro. A polydimethylsiloxane (PDMS) device consisting of a well and a center base with four extruding microposts was developed. Tissue rings were mounted on the posts and exposed to saline solution with or without potassium. Potassium-mediated smooth muscle contraction caused micropost deflection, which was measured with a stereomicroscope and used to calculate force. This presents a method to quantify the contraction response of tissue ring constructs.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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