Faculty Advisor

Adams, David S.

Faculty Advisor

Camesano, Terri Anne

Center

UMMC / University of Massachusetts Medical Center

Abstract

Fungal infections caused by Candida albicans are more common today than ever before. Higher morbidity and mortality rates associated with drug resistance have increased the need for the development of more effective compounds that enhance marketed antifungal activity. In this study, the anticandidal activity of the terpenoid component of the plant essential oil, Geraniol, was investigated. This was achieved using minimum inhibitory concentration assays (MIC) on resistant C. albicans strains. The synergistic activity of Geraniol combined with the known azole Fluconazole was also evaluated using Checkerboard Assays for increased efficacy against C. albicans in vitro. The data indicate a synergistic activity of the Geraniol-Fluconazole mixture against drug-resistant C. albicans.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biology and Biotechnology

Major

Chemical Engineering

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemical Engineering

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