Camesano, Terri Anne
Rao, Reeta Prusty
Fungal infections caused by yeasts of the genus Candida are the fourth most common cause of healthcare-associated bloodstream infections in the United States. Previous research has identified a small molecule, named Filastatin, which reduces the adhesion ability of Candida to surfaces and prevents its ability to form biofilms. The ultimate goal of this project was to develop biophysical techniques to study fungal attachment and how this may be altered pharmacologically using drugs such as Filastatin or genetically using mutants. Atomic force microscopy was used as an experimental technique to determine single-cell adhesion forces of Candida albicans. The experiments conducted will help determine the effectiveness of Filastatin in reducing the adhesion of Candida to medical surfaces.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology