Faculty Advisor

Adams, David S.

Abstract

Gadd45-alpha is a tumor suppressor protein identified by microarray analysis with a reduced expression in hepatocellular carcinoma (HCC) cell lines with high migration ability. The role of Gadd45-alpha in HCC migration was tested by stable shRNA knockdowns in a non-metastasizing murine cell line (BL185). The migration levels of the Gadd45-alpha knockdowns were significantly increased relative to the parental non-metastasizing line, indicating that decreased Gadd45-alpha expression is sufficient to promote increased cell migration.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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