UMMC / University of Massachusetts Medical Center
University of Massachusetts Medical Center
Gasdermin D (GSDMD) is a protein encoded by the GSDMD gene and is found in the epithelial tissue and immune cells of humans. GSDMD is known to be cleaved into two segments, the pore forming domain on the N-terminal and the repressor domain on the C-terminal, by inflammatory caspases 1, 4, 5, and 11. Various bacterial strains were used to infect mouse macrophages with and without the GSDMD gene. The quantified difference in cell death between the two groups emphasizes the role of the GSDMD protein in the pyroptosis pathway.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry