Faculty Advisor

Gericke, Arne

Center

University of Massachusetts Medical Center

Abstract

Gasdermin D (GSDMD) is a protein encoded by the GSDMD gene and is found in the epithelial tissue and immune cells of humans. GSDMD is known to be cleaved into two segments, the pore forming domain on the N-terminal and the repressor domain on the C-terminal, by inflammatory caspases 1, 4, 5, and 11. Various bacterial strains were used to infect mouse macrophages with and without the GSDMD gene. The quantified difference in cell death between the two groups emphasizes the role of the GSDMD protein in the pyroptosis pathway.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Project Center

University of Massachusetts Medical Center

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