Faculty Advisor

Tuzel, Erkan

Abstract

Gliding assays have been the standard tools of the past two decades to analyze the properties of molecular motors. Recently, we have shown that they can be used as model systems to study bending of bio-filaments. There are several approaches in the literature to measure filament deformations. One of the most commonly used approaches is Fourier analysis. In this project, we investigate this technique in great detail using computer simulations, and compare it with another novel technique, namely curvature distributions. We also compare our theoretical predictions and simulation results with experimental measurements of filament bending from actin gliding assays.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Physics

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Physics

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