Gliding assays have been the standard tools of the past two decades to analyze the properties of molecular motors. Recently, we have shown that they can be used as model systems to study bending of bio-filaments. There are several approaches in the literature to measure filament deformations. One of the most commonly used approaches is Fourier analysis. In this project, we investigate this technique in great detail using computer simulations, and compare it with another novel technique, namely curvature distributions. We also compare our theoretical predictions and simulation results with experimental measurements of filament bending from actin gliding assays.
Worcester Polytechnic Institute
Major Qualifying Project
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