Faculty Advisor

Lee, Kwonmoo

Abstract

Glioblastoma is a heterogeneous disease such that the receptors expressed vary based on tumor location. Working with Nemucore Medical Innovations, Inc., theranostic nanoemulsions were designed and manufactured to combat Glioblastoma and other brain diseases. Engineered targeting ligands incorporated in the nanoemulsions assisted in delivery to specific regions. Magnetic Resonance Imaging determined the bio-distribution in healthy rats across the Blood-Brain Barrier. Statistical analysis was completed with T1 MRI data for 174 defined regions. A 3-dimensional heat map program was created to integrate MRI imaging and statistical analysis. In conclusion, data demonstrates targeting ligands on the nanoemulsions alter pharmacodynamics in rat brains, shown by a fully integrated imaging system.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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