Faculty Advisor

Flaherty, Patrick J.

Abstract

Glioblastoma Multiforme (GBM) continues to be a leading form of malignant brain cancer. GBM presents a high variability patient to patient. This provides a need for a theranostic system capable of both delivering therapeutic and in real-time visually observe results. Current methods involve months between treatment application and available results. Based on Nemucore Medical Innovation’s drug delivery vehicles, nanoemulsions (NE) containing chemotherapeutics are being utilized to target cancer cells and reduce systemic toxicity. Through the automation of required statistical analysis and creation of a wire-frame rat brain model with 174 defined brain regions a software capable of providing ‘real-time’ pharmacodynamics analysis of Gd3+ annotated, receptor-targeted NE is one step closer.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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