UMass Medical School
Glucan particles (GPs) are hollow, porous glucan shells extracted from Baker's yeast. Due to their composition there is efficient receptor-mediated particle uptake by cells expressing glucan receptors. Mesoporous silica nanoparticles (MSNs) are materials synthesized from tetraorthosilicate reacting on a template to produce particles with pores. A model combined GP/MSN drug delivery system was developed using the drug Doxorubicin (Dox) and the antibiotic Rifampicin (Rif). The GP/MSN system benefits from the macrophage targeting capabilities of GPs and small drug molecule binding capacity of MSNs. GP/MSN-Rif complexes were studied for their effect on inhibiting E. coli growth. GP/MSN-Dox complexes were evaluated for Dox delivery and growth arrest of the model murine cell line.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry
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