Faculty Advisor

Heilman, Destin

Abstract

Glucan particles (GPs) are hollow, porous glucan shells extracted from Baker's yeast. Due to their composition there is efficient receptor-mediated particle uptake by cells expressing glucan receptors. Mesoporous silica nanoparticles (MSNs) are materials synthesized from tetraorthosilicate reacting on a template to produce particles with pores. A model combined GP/MSN drug delivery system was developed using the drug Doxorubicin (Dox) and the antibiotic Rifampicin (Rif). The GP/MSN system benefits from the macrophage targeting capabilities of GPs and small drug molecule binding capacity of MSNs. GP/MSN-Rif complexes were studied for their effect on inhibiting E. coli growth. GP/MSN-Dox complexes were evaluated for Dox delivery and growth arrest of the model murine cell line.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Chemistry

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Your accessibility may vary due to other restrictions.

Share

COinS