Hcm1 is a cell cycle-regulatory transcription factor in budding yeast, which activates several mitotic spindle regulatory genes. Its human homolog, FoxM1, is overexpressed in a number of human cancers. Preliminary data indicates that Cdk1 phosphorylation is required for Hcm1 activity but the consequences of this phosphorylation at the molecular level are not well understood. I developed a screen to identify the specific Cdk phosphorylation sites that are important for Hcm1 function, in order to understand how phosphorylation stimulates its activity.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Poti, Kristin Elizabeth

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042914-165548

Advisor

• Rao, Reeta Prusty

Year

• 2014

Sponsor

• Dr. Jennifer Benanti

Date created

• 2014-04-29

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright