Faculty Advisor

Rao, Reeta Prusty

Center

UMMC / University of Massachusetts Medical Center

Abstract

Hcm1 is a cell cycle-regulatory transcription factor in budding yeast, which activates several mitotic spindle regulatory genes. Its human homolog, FoxM1, is overexpressed in a number of human cancers. Preliminary data indicates that Cdk1 phosphorylation is required for Hcm1 activity but the consequences of this phosphorylation at the molecular level are not well understood. I developed a screen to identify the specific Cdk phosphorylation sites that are important for Hcm1 function, in order to understand how phosphorylation stimulates its activity.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biology and Biotechnology

Major

Humanities and Arts

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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