Gaudette, Glenn R.
Heart failure is one of the leading causes of death worldwide. Currently, heart transplantation is the treatment of choice for end-stage heart failure, but lack of donor hearts and risk of rejection remain a challenge. Research has shown that decellularized hearts, in which cells are removed from the cardiac extracellular matrix (ECM), can provide a scaffold for use in engineering patient-specific heart transplants. This project presents a low-cost, semi-automated, small-organ (ie. rat heart) decellularization bioreactor designed for cardiac research, Testing has shown that this device can successfully decellularize rat hearts, and offers functionality similar to commercial devices.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.