Faculty Advisor

Gaudette, Glenn R.

Abstract

Heart failure is one of the leading causes of death worldwide. Currently, heart transplantation is the treatment of choice for end-stage heart failure, but lack of donor hearts and risk of rejection remain a challenge. Research has shown that decellularized hearts, in which cells are removed from the cardiac extracellular matrix (ECM), can provide a scaffold for use in engineering patient-specific heart transplants. This project presents a low-cost, semi-automated, small-organ (ie. rat heart) decellularization bioreactor designed for cardiac research, Testing has shown that this device can successfully decellularize rat hearts, and offers functionality similar to commercial devices.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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