Faculty Advisor

Medich, David Christopher

Abstract

High-dose rate brachytherapy is a type of treatment of cancer whereby a radioactive source is inserted directly into the tissue or its nearest vicinity for short time intervals, damaging the DNA of rapidly dividing cancer cells and triggering cell death. This study considers Ytterbium-169, a high-energy photon source, as an alternative to Iridium-192, the current HDR brachytherapy standard. We demonstrate that Ytterbium-169 performs as successfully as Iridium-192 in delivering a high, uniform dose to soft tissues, but results in an unfavorably high dose to bone tissue. We suggest that Ytterbium-169 is a promising target for intensity modulated brachytherapy.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Physics

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Physics

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