High-throughput screening of C. elegans can be used to identify drugs for treatment of neuropsychiatric disorders. These experiments are currently conducted manually, which is time-consuming and hands-on. We designed an automated chemical delivery system, using open-source electronics and rapid prototyped hardware, costing <$300. Our system sequentially delivers chemicals from a 96-well microplate, with low cross-contamination (<0.01%) and satisfactory switching speed (<1 min) between chemicals. We validated our system by reproducing dose-response results published in previous C. elegans literature.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Biernacki, Thomas Brian
• Altshuler, Benjamin Minich
• Zayas, Michelle Joann
• Shastry, Sneha Priya

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043015-132319

Advisor

• Albrecht, Dirk

Year

• 2015

Date created

• 2015-04-30

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright