Faculty Advisor

Albrecht, Dirk

Abstract

High-throughput screening of C. elegans can be used to identify drugs for treatment of neuropsychiatric disorders. These experiments are currently conducted manually, which is time-consuming and hands-on. We designed an automated chemical delivery system, using open-source electronics and rapid prototyped hardware, costing <$300. Our system sequentially delivers chemicals from a 96-well microplate, with low cross-contamination (<0.01%) and satisfactory switching speed (<1 min) between chemicals. We validated our system by reproducing dose-response results published in previous C. elegans literature.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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