High-throughput screening of C. elegans can be used to identify drugs for treatment of neuropsychiatric disorders. These experiments are currently conducted manually, which is time-consuming and hands-on. We designed an automated chemical delivery system, using open-source electronics and rapid prototyped hardware, costing <$300. Our system sequentially delivers chemicals from a 96-well microplate, with low cross-contamination (<0.01%) and satisfactory switching speed (<1 min) between chemicals. We validated our system by reproducing dose-response results published in previous C. elegans literature.
Worcester Polytechnic Institute
Major Qualifying Project
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