Paul Kaufman, PhD. of UMass Medical School
Histone deposition proteins CAF-1 and Asf-1 impact multiple aspects of chromosome formation and are essential in yeast to prevent DNA damage and avoid chromosomal rearrangement. Using fractionated yeast cell extracts, this MQP attempted to identify stimulatory factors which are necessary and sufficient for histone deposition by CAF-1 and/or Asf1. Identification of these cofactors, would provide insight into the reaction pathway and mechanism of histone deposition. Results were inconclusive, but improvements were proposed for the future success of this project.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology