Faculty Advisor

Rulfs, Jill

Abstract

Histone deposition proteins CAF-1 and Asf-1 impact multiple aspects of chromosome formation and are essential in yeast to prevent DNA damage and avoid chromosomal rearrangement. Using fractionated yeast cell extracts, this MQP attempted to identify stimulatory factors which are necessary and sufficient for histone deposition by CAF-1 and/or Asf1. Identification of these cofactors, would provide insight into the reaction pathway and mechanism of histone deposition. Results were inconclusive, but improvements were proposed for the future success of this project.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2007

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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