Adams, David S.
UMass Medical School
HIV is a highly mutable virus that has become a global pandemic. In order to prevent further spread of this disease a topical microbicide that is cheap and easy to administer and produce is necessary. Our project involved the extraction of the HIV drug Nevirapine from commercial tablets to encapsulate it inside glucan particles for mucosal delivery. Glucan Particles (GP) are naturally internalized by macrophages and Langerhans cells thought to be the first cells to be HIV infected at mucosal sites. GP are hollow microparticles derived from baker's yeast that can be used to absorb the Nevirapine into an encapsulated core. To keep the drug trapped inside the core various synthetic strategies were evaluated to identify an effective formulation for future in vitro and in vivo testing.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology