Faculty Advisor

Adams, David S.

Abstract

Human Cytomegalovirus (HCMV) infection can progress into a persistent and life-threatening disease in infants and immune-compromised individuals, especially when resistant to available antiviral therapies. The purpose of this project was to study two proposed cellular activation pathways of antiviral drug MBX 2168, a nucleoside analog that inhibits viral DNA replication. This project specifically examined the de-alkylation of MBX 2168 monophosphate (upper pathway) and mono-phosphorylation of synguanol by viral-encoded kinase UL97 (lower pathway). The results indicate that both pathways theoretically participate in drug activation, but the cell prefers the upper pathway for MBX 2168 activation.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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