Faculty Advisor

Gibson, Daniel G

Abstract

Immunohistology and a partial DNA sequence confirm the presence of the vertebrate neurotrophic factor ependymin in the horseshoe crab. We hypothesized that ependymin concentrates at sites of limb regeneration. We treated regenerating limb stumps prepared for light and electron microscopy with rabbit anti-ependymin (controls: normal rabbit serum) and goat anti-rabbit reporter antibodies. Ependymin is present at wound sites, but also diffusely present in limbs freshly removed from intact controls. Ependymin is likely necessary for normal growth as well as regeneration.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2005

Major

Biology and Biotechnology

Major

Mathematical Sciences

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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